Volumes Archive
Vol. 45, Number 3, 2003
The Effects of Sodium Arsenite on Glutathione and Malondialdehyde Levels in Mice Tissues
Sodyum Arsenitin Fare Dokularında Malondialdehit ve Glutation Düzeyine Etkisi
Aybike Dip*, Şahan Saygı**, Şebnem Ş. Çeçen* and Tülin Söylemezoglu*
*Ankara University, Institute of Forensic Medicine, Dikimevi, Ankara / TURKEY
**Gulhane Military Medical Academy, Depaltment of Analytical Toxicology, Ankara/TURKEY
Abstract
In this study, the oxidative damage of sodium arsenite (NaAs02 ) was investigated by measuring the malondialdehyde (MDA) and glutathione (OSH) levels. NaAs02 was administered Swiss Albino mice (35 mg/kg) and sacrificed after one hour. MDA and GSH levels were determined in liver, kidney, brain and heart tissues by UV-Spectrophotometric methods. After NaAs02 treatment MDA levels decreased in liver, brain and kidney (p<0,001), on the other hand, increased significantly in heart tissues (p<0,01). No alteration was observep in liver and kidney OSH levels, however, NaAs02 caused significant depletion in GSH in both heart and brain (p<0,01) tissues.
Key words: Sodium arsenite, lipid peroxijation, glutathione, malondialdehyde
