Volumes Archive
Vol. 45, Number 3, 2003
Synthesis and Anti-Inflammatory Activity of Some 10-[(1-Acyl-1h-Tetrazol-5- YI)Ethyl]-10h-Phenothiazines
A.Rajasekaran and P.P.Thampi
Medicinal Chemistry R & D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626 190, TamilNadu. INDIA.
Abstract
A series of novel 10-[(1-Acyl-1h-Tetrazol-5- YI)Ethyl]-10h-Phenothiazines (I-XII) have been synthesized by reacting 10-[(1h-Tetrazol-5- YI)Ethyl]-10h-Phenothiazines and desired acylating/sulphonating reagents. 10-[(1-Acyl-1h-Tetrazol-5-YI)Ethyl]-10h-Phenothiazines was synthesized by cyanoethylation of phenothiazine nucleus with acrylonitrile and Triton-B followed by the conversion of nitrile group to 1,2,3,4-tetrazole in presence of sodium azide and ammonium chloride. All the compounds were characterized by elemental analysis, lR spectra and NMR spectra. The compounds synthesized were screened for anti-inflammatory activity. Compounds IV and VI are found to possess potent anti-intlammatory activity.
Key words: Phenothiazine; tetrazoles; anti-inflammatory activity.
